What is Sucralose? Can It Have Bad Health Impacts?

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What is Sucralose? Can It Have Bad Health Impacts?

It is evident and proven now that too much use of sugar is harmful and can turn into a killer if you are Diabetic. So, What to do now? It’s not rational optional to live a dull, boring, and sugar-free life.

This is the reason people avoid sugars and prefer low-calorie or zero-calorie artificial sweeteners. They include low-calorie Aspartame1 to zero-calorie Sucralose.

You must have been familiar with Sucralose available in Yellow packaging in stores. It is used as a substitute for natural sugar and is considered healthy. The article aims at revealing the facts that either it can be a proper, healthy substitute for a real thing or not.

So, let’s discuss all the possible aspects that, What is Sucralose? Is Sucralose bad for you? Is Sucralose as bad as aspartame?

What Is Sucralose?

what is sucralose can it have bad health impacts

We all know how important it is to restrict our intake of sugar and sweets to maintain a balanced diet.

What about artificial sweeteners, on the other hand? Sugar substitutes are popular among people watching their carbohydrate and calorie intake.

Sucralose, often known as Splenda2, is the newest artificial Sweetener. Here’s all you should know about this sugar substitute.

Sucralose can be referred to as a food additive and used in place of normal sugar. It aims at 600 times sweeter than sugar and is essentially sugar-free. This is the reason this is used as artificial sugar.3

Like other sugar, Sucralose is also placed on a controversial list. Some advocate it completely hygienic while others place it on the health risk list. It is suggested that it can affect metabolism in a certain way.

History Of Sucralose

It was invented in 1976 after a scientist at a British university misheard instructions about evaluating a chemical. Instead, he took a bite and noticed how sweet it was.

After that, Tate & Lyle and Johnson & Johnson collaborated to create Splenda products. This product was first released in the United States in 1999 and has since become one of the country’s most popular sweeteners.

Structure Of Sucralose

Sucralose is a semisynthetic sweetener that replaces three hydroxyl groups on sucrose with chlorine atoms (4′, 1′, and 6′ locations) to improve sweetness.2

General Properties Of Sucralose

general properties of sucralose

C12H19O8Cl3 is its chemical formula (MW 397.35). Sucralose is a crystalline powder that is white and odorless and is easily dispersed and soluble in water, methanol, and ethanol.

Sucralose in water can be made into a 280 g per liter solution at 20 °C. Sucralose has Newtonian viscosity, a minor reduction in surface tension, and no pH effects, and its solubility increases as the temperature rises.

Its solubility in ethanol ranges from roughly 110 g per liter at 20 °C to 220 g per liter at 60 °C, making it helpful in formulating alcoholic beverages and taste systems.

Sucralose has a sweetness of 400–800 times that of sucrose. Sucralose has an unmistakable sugar-like taste and a time-intensity profile similar to sucrose.

 It has varying PH. It has a great flavor profile with no harsh or unpleasant aftertaste.

Is it Safe To Consume Sucralose?

is it safe to consume sucralose

Artificial sweeteners have grown popular as sugar alternatives. They’re also thought to reduce hunger and appetite. As a result, it is popular among those who want to lose weight, control diabetes, or manage metabolic illnesses.

Even though the FDA has approved several artificial sweeteners for human consumption and labeled them as “generally safe,” they must be ingested in specified amounts to avoid negative consequences.

Age, sex, nutritional state, and physical activity influence how much energy or calories a person requires. It means that if you want to use artificial sweeteners, you’ll have to calculate your daily intake depending on these criteria. There is no such thing as that same amount of food that fits all sizes.

Sucralose has an acceptable daily intake (ADI) of 5 milligrams (mg) per kilogram (kg) of body weight per day, according to the FDA. The JECFA gave Sucralose an ADI of 0-15 mg/kg of body weight per day in 1991.5

The article aims at checking various health impacts of Sucralose from different aspects. So, let us examine if it is safe to use or not.

Is Sucralose Safe To Use In Pregnancy

No indication of birth deformities or other detrimental effects on pregnancy has been found in high-quality research in pregnant animals using any of these sweeteners.

However, artificially sweetened foods and drinks are often devoid of nutrients, a health concern for pregnant women. You won’t reap the benefits of more healthy foods and beverages if you fill up on a diet Coke or sweet foods.6 

Is it Safe To Use Sucralose While Breastfeeding?

Breast milk samples were taken from 20 breastfeeding participants, regardless of whether they regularly consumed non-nutritive sweeteners (NNS).

In 65 percent of the participants’ milk samples, saccharinSucralose, and acesulfame-potassium were found, but aspartame was not. 

These findings suggest that NNS are commonly transferred to nursing newborns, necessitating.

Prospective clinical trials to evaluate whether early NNS exposure via breast milk has clinical consequences.7

Can Children Consume Sucralose

Any artificial Sweetener, including Sucralose, is not recommended for children. Sugar also lacks nourishment in fiber, vitamins, and minerals.

As a result, if sugar accounts for a considerable portion of a child’s calorie intake, they are likely to miss out on other meals that supply vital nutrients for growth and development.

Some studies make Sucralose suspect for the increase of Bowel disease in children.8 Another study blames Sucralose as not safe for children as it concentrates in the plasma of children and adults after consumption.9

Is Sucralose A Cause Of Teeth Decay

Many oral and edible products, for example, sugar, are made of Sucralose. Sucralose is a sugar substitute that does not affect tooth decay. Sucralose-based sweeteners include no extra sweetening compounds that are damaging to teeth.10

Sugar is an issue because it causes cavities. However, this occurs solely when specific bacteria devour the sugar and produce acids. In reality, tooth decay is caused by the acids produced by sugar.11

If we talk about the impact of artificial sweeteners on the teeth, the answer is they can be both harmful and beneficial.

Sugar replacements are frequently included in beverages and sweets that contain potentially dangerous acidic components.

 The good thing is that artificial sweeteners do not feed the bacteria in your mouth to make acids as sugar does.

Citric acid and phosphoric acid are the most common causes of tooth decay. They’re used to impart tanginess to sugar-free candies and colas.

While they are tasty, they are also harmful to your teeth. On the other hand, Artificial sweeteners do not protect your teeth from acid damage.12

Can Sucralose Cause Cancer

When early investigations demonstrated that combined cyclamate with saccharin induced bladder cancer in experimental animals, artificial sweeteners and cancer arose.

However, further carcinogenicity studies of these sweeteners have not shown clear evidence of a link between these sweeteners and cancer in people.

Similarly, no firm evidence of a link with cancer in humans has been found in investigations of other FDA-approved sweeteners. It was a matter of concern to test Sucralose for such tests.

 After the same repeated experiments, metabolites of Sucralose were determined to have no carcinogenic risk in investigations during the experimental work.

Sucralose was determined to have no potential for carcinogenicity or genotoxicity, even at high dosages.

The FDA has approved the use of Sucralose in the consumer market without limits, based on more than 110 investigations (physicochemical and pharmacokinetic/toxicokinetic studies) conducted in the lab, in animals, and humans.12 

Impact Of Sucralose On Weight Gain And Obesity

In large-scale population studies, artificial sweetener usage, particularly in diet sodas, has been linked to weight gain and belly fat growth over time.13

Non-nutritive sweeteners (NNSs) are used instead of regular Sweeteners that can be used to satisfy a sweet tooth while lowering caloric intake.

However, investigations on the effects of NNSs on hunger and the links between sex and obesity have yielded inconsistent results.14

A study indicates that women and obese persons showed higher activity in the brain’s reward area after drinking a drink sweetened with Sucralose rather than sugar. Women ate more food at a post-fasting buffet.

More use of artificially induced Sweetener may trigger more appetite and thus increase obesity risk level.15

Data from the study suggests that females, particularly females with obesity, may be more sensitive to the increased neuronal response produced by Sucralose ingestion than sucrose consumption.

This study emphasizes the importance of taking individual biological parameters into account in research investigations and, perhaps, dietary advice, including the use and efficacy of NNS for weight loss.

What Does Splenda Do to your Gut?

Many beneficial bacteria have been found in the human stomach and digestive tract, aiding indigestion. They help with digestion, immune system support, and recovery from other illnesses. Artificial sweeteners can wreak havoc on your digestive system.

In a mouse study, unfavorable effects on gut-friendly bacteria were discovered. Sucralose consumption reduces the number of microbes in rats, according to research.

They determined that after ingesting Sucralose, anaerobic bacteria reduced by 47% to 80%.

They watched that the quantity of bifidobacteria declined. Similarly, Lectic aid bacteria were reduced, and other good bacteria were reduced due to the modest influence on hazardous bacteria.

Even after the experimental investigation, the number of helpful bacteria did not return to normal. Even though this study was performed on the mice, it is still a cause for alarm.16 Scientists must also be inventive.

Is Sucralose Associated with Heart Attacks?

According to new research, the artificial Sweetenersweetener Sucralose may raise the risk of stroke and other heart disorders.

According to a study, those who regularly use artificial sweeteners in drinks and beverages for up to a week are three times more likely to suffer a heart attack than those who do not.17

However, there is no direct link between artificial sweeteners and heart disease because this was an observational study. Other studies have shown that using Sucralose as an artificial sweetener has no meaningful impact. 

Additional research is needed to provide more clarification. Sucralose does not act on the bloodstream right away.

Some studies have shown that the constant use of artificial sweetener Sucralose may increase the risk of stroke and other heart diseases.

A study has found that people who use artificial sweeteners in drinks and beverages daily, for a period of up to a week are at risk of heart attack 18thrice than others who do not use Sucralose.

But this was an observational study and cannot prove well a direct link between the use of artificial sweeteners and heart diseases.

Other investigations have also been made that proved that the use of Sucralose is an artificial sweetener has no significant impact. more studies are needed to bring more clarity.

Is Sucralose Bad or Harmful For Diabetics?

Mostly, Sucralose is considered safe for Diabetics and does not affect insulin and blood sugar level. This is because Sucralose does s Recent studies have proved something otherwise.

In a recent research19, a group of scientists studied mice behavior after constant use of artificial sweeteners. Results revealed that constant use of artificial sweeteners interrupted their blood glucose level and they became intolerant towards glucose level.

In another research study20, 17 obese people were investigated who do not use artificial sweeteners regularly. They were shown to have some changes in their blood sugar and insulin level. Their blood sugar level was increased to 14% and insulin level to 20%.

In another study, people with average weight were investigated who do not use artificial sweeteners constantly. They were observed with no impacts on blood sugar and insulin level

Sucralose is generally regarded safe for people with diabetes, as it does not affect insulin or blood sugar levels. Sucralose does not have an immediate effect on blood sugar and insulin levels. Recent research has shown that this is not the case.

A group of experts looked at the behavior of mice after they were given artificial sweeteners regularly in a recent study.

The results showed that artificial sweeteners regularly disrupted their blood glucose levels, causing them to become glucose intolerant.

In a separate study, 17 obese adults who do not use artificial sweeteners regularly were evaluated.

They noticed that their blood sugar and insulin levels had changed. Their blood sugar level was raised to 14%, and their insulin level was raised to 20%.

Another study looked at adults of average weight who did not use artificial sweeteners regularly. Blood sugar and insulin levels were unaffected.

Is it Safe to Use Splenda at High Temperature?

Sucralose’s effects and stability have been investigated in safety studies under normal use conditions. However, some researchers have looked into what happens when overheated Sucralose, such as cooking.

 There is more concern with this setting (even with moderate heating). Sucralose produces chloropropanols, potentially hazardous chemicals when cooked at high temperatures. If you want to prevent this risk, don’t use Splenda in your cooking and baking.21

Is Sucralose A Cause Of Dementia?

An impact of sucralose over Dementia was studied by the same group that conducted experiments for cardiovascular diseases and heart stroke.

Here, they also observed the same ambiguity in results and cannot find a direct linkage between Dementia22. Anyways they suggested clinical trials to understand it more elaborately.

Why Is Sucralose So Bad For You?

Although Sucralose has been considered safe for a while latest study has brought some new revelations into the light. Sucralose can affect the gut system. It can also have harmful impacts on Diabetics.

It may increase the heart stroke rate and can be a cause to increase obesity. It can also become a cause of Dementia. Baking with these artificial sweeteners can also become harmful in certain cases.

The Bottom Line

Although Sucralose is a great substitute for natural sugar. It is giving you more sweetening in zero calories, but hold on yet!

As we see Sucralose is associated with various health risks including the risk of type 2 diabetes. It disturbs the function of insulin and glucose level.

It causes harm to important beneficial bacteria and may cause a mess to your cardiovascular system.

So, here is needed to be cautious. Your amount of consuming sugar should be limited as compared to being addicted to it.

Your health is more important than your taste buds. So; you should eliminate or minimize the use of both normal and artificial sugars in your diet.


1-Brennan, D. (2021, June 8). Sucralose: Facts and safety of Splenda. WebMD.

2-Butchko, H. H., Stargel, W. W., Comer, C. P., Mayhew, D. A., Benninger, C., Blackburn, G. L., … & Trefz, F. K. (2002). Aspartame: review of safety. Regulatory Toxicology and Pharmacology35(2), S1-S93.

3-Sucralose. Sucralose – an overview | ScienceDirect.

4- Sharma, A., Amarnath, S., Thulasimani, M., & Ramaswamy, S. (2016).

 Indian journal of pharmacology.

5-Food safety. (n.d.). Retrieved December 6, 2021

6- Hallie Levine, writer|M. reviewed byE. H. (n.d.). Which artificial sweeteners are safe during pregnancy?

7-Sylvetsky, A. C., Gardner, A. L., Bauman, V., Blau, J. E., Garraffo, H. M., Walter, P.J.,& Rother, K. I. (2015).

8-Surgery, D. of. (n.d.). Food additives: Possible cause for recent remarkable…: Journal of  Pediatric Gastroenterology and Nutrition.

9- Sylvetsky, A. C., Bauman, V., Blau, J. E., Garraffo, H. M., Walter, P. J., & Rother, K. I. (2017). Toxicological and environmental chemistry.

10-Nature Publishing Group. (2018, January 12). Alternative sugars: Sucralose. Nature News.

11-Sugar, artificial sweeteners, and your teeth: Angela Evanson, DDS in Parker, Co Dentist:(720) 409-0008: 80134. Angela S. Evanson, DDS. Dentist in Parker, CO. (2019, February 12)  

12-Dental, C. (n.d.). Nineteen excellent home remedies for removing plaque naturally.

Carefree Dental.

13-Fayed, L. (n.d.). Do splenda or sucralose cause cancer? Verywell Health.

14-Not sweet nothings: Why Splenda and stevia can make you gain weight. Forks Over Knives.  (2019, December 13).

15-Alexandra G. Yunker, B. A. (2021, September 28). Differential effects of Sucralose vs sucrose on appetite and reward processing. JAMA Network Open.

16-West, C. E., Renz, H., Jenmalm, M. C., Kozyrskyj, A. L., Allen, K. J., Vuillermin, P.,

 Prescott, S. L., & Group, in-F. L. A. M. E. M. I. (2017, November 16).

17-Abou-Donia, M. B., El-Masry, E. M., Abdel-Rahman, A. A., McLendon, R. E., & Schiffman,S. S. (2008). Journal of toxicology and environmental health.

18-Pepino, M. Y., Tiemann, C. D., Patterson, B. W., Wice, B. M., & Klein, S. (2013,


19-Pase, M. P., Himali, J. J., Beiser, A. S., Aparicio, H. J., Satizabal, C. L., Vasan, R. S., Seshadri, S., & Jacques, P. F. (2017, May). Sugar- and artificially sweetened beverages and the risks of incident stroke and dementia: A prospective cohort study

20- Gilmerm. (2021, August 2). Is sucralose bad for you? the truth about splenda. Cleveland Clinic. Retrieved November 30, 2021

21-Guest. (n.d.). Thermal degradation of Sucralose: A combination of analytical methods to determine stability and chlorinated byproducts.

22-Pase, M. P., Himali, J. J., Beiser, A. S., Aparicio, H. J., Satizabal, C. L., Vasan, R.S.,Seshadri, S., & Jacques, P. F. (2017). Sugar- and artificially sweetened beverages and the risks of incident stroke and dementia: A prospective cohort study: A prospective cohort study. Stroke; a Journal of Cerebral Circulation, 48(5), 1139–1146.

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